Comparative in Vitro Dissolution Assessment of Some Commercially Available Paracetamol Tablets

Various commercially available paracetamol tablets (500 mg) were evaluated comparatively for in vitro dissolution qualities along with drug content (assay). The assay results ascertain the presence and compendial quality of paracetamol in all these products. The in vitro dissolution profiles were found to be varying for each tablet, but within the prescribed limit. The dissolution at 15 minutes (t15 min, %) and 50 % of dissolution (D50 %, min) were also determined. The paracetamol tablet, C exhibited highest dissolution (%) in 15 minutes (80.85 ± 1.84 %) and lowest value of 50 % dissolution (3.75 ± 0.18 min) along with comparatively highest drug content (99.78 ± 0.49). Statistical assessment of various in vitro dissolution parameters and assay results was also conducted to establish if there were any significant difference among them.